QMB Signalling Programme

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The meeting will have sessions focussing on Signalling Pathways in Cancer, GPCR Signalling, Signalling Pathways Regulating Metabolism, Signalling Pathways Regulating Gene Expression, Redox Species and Signalling, Signalling in Plants, Cardiovascular Signalling.

Sunday 28th August
8.30 - 9.45am	Drug Discovery and Signalling Pathways Peter Shepherd, University of Auckland: Developing drugs targeting PI 3-kinase pathway *Jeanette Wood, SBio, Singapore: TBC Christina Buchanan, University of Auckland*: Finding new targets for DMXAA*(Short Talk)
9.45 - 10.15am	Morning Tea
10.15 -12:15 pm	Signalling in Cardiovascular Tissues (Joint with Heart Satellite) Jorgen Jensen, Oslo University: Complex cross-talk between insulin and b-adrenoceptor stimulation regulates PKB phosphorylation in rat cardiomyocytes Julie McMullen, Baker Heart Institute, Melbourne: Role of the IGF1-PI3K pathway in the heart/ Targeting genes in the athlete's heart to treat heart failure Regis Lambert, University of Otago: AMPK: cardiac regulator during metabolic stress
12.15 - 1.15pm	Lunch
1.30 - 3.30	Redox Signalling (Joint with Plant Satellite) Simon Gilroy, University of Wisconsin: Abiotic stress and development: links through Ca2+ and ROS-dependent signalling cassettes Christine Winterbourn, University of Otago, Christchurch: Redox signalling: principles, promise and pitfalls Barry Scott, Massey University, Palmerston North: Oxidative stress signalling in Epichloe festucae, a mutualistic fungal symbiont of grasses Mark Hampton, University of Otago, Christchurch: Peroxiredoxins as redox sensors and signalling proteins
4.00-6.00pm	GPCR From Signalling to Drug Discovery Patrick M Sexton, Monash Institute of Pharmaceutical Sciences: Drug action and signal bias at the glucagon-like peptide-1 receptor Michelle Glass, University of Auckland: Trafficking of cannabinoid receptors: implications for drug tolerance Debbie Hay, University of Auckland: The quest for adrenomedullin receptor antagonists for cancer Nigel Bunnett, Monash Institute of Pharmaceutical Sciences: TBC
6.30 - 8.30pm	Mixer and poster session

Monday 29th August
8.30 - 10.30am	Signalling in Metabolic Tissues (II) Andrew Butler, Scripps Institute, Florida, USA: Dissecting MC3R signalling using Cre/Lox technology reveals a role for ventromedial hypothalamic MC3R in metabolic homeostasis George Muscat, Queensland Institute for Molecular Bioscience, Brisbane: The nuclear receptor, RORalpha, regulates lipid and carbohydrate metabolism Kathy Mountjoy, University of Auckland: Diverse roles for Melanocortin Receptor Accessory Proteins in metabolism Greg Smith, University of Auckland: Signalling pathways in liver metabolism
10.30 - 11.00am	Morning Tea
11.00-1.15pm	Other Signalling Pathways Andy Morris, University of Kentucky: Multifunctional Regulation of Lipid Metabolism and Signaling by Lipin 1 Aimin Xu, Hong Kong University: Cross-talk between insulin and adiponectin signaling: Molecular mechanisms and physiological implications Evelyn Sattlegger, Massey University, Albany: Revealing novel links between protein synthesis and the nutrient sensor Gcn2 Emmanuelle Cognard, University of Auckland: Nutrient regulation of Wnt/beta-catenin signaling pathways (Short talk) Ye Guan Chen, Tsing Hua University, Beijing: Wnt signalling and autophagy
1.15-2.15pm	Lunch
2.15-4.15pm	Signalling Pathways and Cancer Jeong Park, Massey University, Palmerston North: TRRAP to SANTA: Roles of TRRAP-p400 complex from transcription to signal transduction pathway Mark Gutheridge, University of Melbourne: Cytokine signalling in leukemia David Fruman, University of California, Irvine: PI 3-kinase pathway and leukemia Wayne Phillips, Peter MacCallum Cancer Centre, Melbourne: PI 3-kinase signalling in cancer Satellite meeting closes.

Those staying on are welcome to attend plenary lecture at opening of QMB meeting by Prof Barry Marshall who won the Nobel Prize for Medicine in 2005 and afterwards the Illumina party that follows (venue to be announced later).

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